DNA Repair Mechanisms in Cancer
LUXEMBOURG INSTITUTE OF HEALTH
Luxembourg, Luxembourg
il y a 3j

Topic description

The DNA Repair and Chemoresistance Group headed by (Department of Cancer Research (DoCR)) carries out fundamental and translational research on the molecular mechanisms governing DNA repair, chromatin dynamics and chemoresistance in cancer.

Our main research interest resides in the identification & validation of novel DNA-repair based strategies to improve cancer treatment, with a particular focus on gliomas (see for instance : Nucleic Acids Res.

2021, 49(17) : 9906-9925. doi : 10.1093 / nar / gkab785).

We have received funds from the FNR under the Bilateral AFR research grant scheme, to undertake a collaborative project with the Group of Dr.

Jean-Yves Masson ( Centre de Recherche du CHU de Québec & Départment de Biologie Moléculaire, Biochimie Médicale et Pathologie, Université Laval, Québec).

Through this bilateral international cooperation, the selected candidate will benefit from training opportunities in both institutions and countries, as well as joined supervision by Drs Van Dyck and Masson.

Although the majority of the research activities will be carried out at LIH, the selected candidate will spend at least 20% of his / her research time in Québec.

The goal of this project is to investigate and target the molecular mechanisms underlying the repair of DNA double-strand breaks associated with the collapse of replication forks, induced by chemotherapeutic DNA damaging agents.

Funding category

Partial or full private funding (CIFRE agreement, foundation, association)

Funding further details

AFR Bilatéral

Presentation of host institution and host laboratory

Luxembourg Institute of Health

The Luxembourg Institute of Health (LIH) is a public biomedical research organisation focused on precision health and invested in becoming a leading reference in Europe for the translation of scientific excellence into meaningful benefits for patients.

LIH places the patient at the heart of all its activities, driven by a collective obligation towards society to use knowledge and technology arising from research on patient-derived data to have a direct impact on people’s health.

Its dedicated teams of multidisciplinary researchers strive for excellence, generating relevant knowledge linked to immune related diseases and cancer.

The institute embraces collaborations, disruptive technology and process innovation as unique opportunities to improve the application of diagnostics and therapeutics with the long-term goal of preventing disease.

Website :

https : / / www.lih.lu /

PhD Student

Country where you obtained your PhD

Key Accountabilities

  • Participate in the setting-up and implementation of a collaborative, international research project in Luxembourg and Québec
  • Conduct a research project with the aims of submitting a PhD thesis dissertation and obtaining a PhD degree
  • Publish her / his results in scientific journals and / or file patents if applicable
  • Disseminate her / his results to the scientific community and the public
  • Key Skills, Experience and Qualifications

  • Master’s degree (or equivalent degree) in biochemistry or molecular biology, with a solid background and research experience in cancer biology and DNA repair
  • Wet laboratory and analytical skills, demonstrated experience in cell culture, nucleic-acids and protein characterization, as well as in RNAi & CRISPR-cas9 technology and bioinformatics will be considered as strong assets
  • Excellent time management, rigour, perseverance, scientific creativity and originality, writing skills, conciseness, sense of priority and ability to work with others
  • Language skills : fluent command of English and strong knowledge of French; knowledge of other languages of the European Union is an asset
  • Application deadline 2022-10-07

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