Chronic Lymphocytic Leukemia (CLL) represents the most frequent leukemia in adults. Despite recent advances in treatments, CLL remains a deadly uncurable disease.
This cancer is caracterized by an accumulation of abnormal, apoptosis resistant, B lymphocytes in the blood and lymphoid organs of the patients.
CLL progression is highly dependent on complex interactions between tumor cells and their microenvironment. Indeed, CLL cells can modify stromal cells and immune cells to promote their survival and to escape from the immune surveillance system
Our teamfocuses on the mechanisms leading to leukemia progression, in particular theinfluence of CLL cells on stromal cells and immune cells located in theirmicroenvironment, with the goal to identify new prognostic markers andtherapeutic targets.
Training and research environment
Tumor Stroma Interactions research group is a dynamic and multinational team whose current members originate from France, Belgium, Germany and Italy.
It belongs to the Department of Oncology, whose research activities focus on the cellular and molecular mechanisms of tumor progression using a wide range of cutting edge technologies, including genomic, transcriptomic and proteomic analyses, as well as in vitro and in vivo imaging modalities using state-
of-the art animal models for cancer research. Master students will assist one of our projects that aims to explore the interplay between leukemic cells and their microenvironment, and will be co-
supervised by Dr. E. Moussay (PI), Dr. J. Paggetti (PI) and experienced scientists from the team.
Recent related reference (open access) : Paggetti J, et al. Exosomes released by chronic lymphocytic leukemia cells induce cancer-
associated fibroblast formation. Blood 126(9) : 1106-17.
Wierz M, et al. Dual PD1 / LAG3 immune checkpoint blockade limits tumor development in a murine model of chronic lymphocytic leukemia.
Blood 131(14) : 1617-1621. (IF : 13.164)
What we offer and conditions
time PCR,and cell culture, as well as confocal imaging, flow cytometry and in vivo experiments on mouse models.