Researcher in Molecular and Cellular Biology of Cancer (m/f)
Laboratoire de Biologie Moleculaire et Cellulaire du Cancer LBMCC
Luxembourg, Luxembourg
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source : StepStone

PhD thesis position in Molecular and Cell biology Targeting Acute Myeloid Leukemia sphingolipid metabolism

Laboratoire de Biologie Moléculaire et Cellulaire du Cancer (LBMCC), Luxembourg

LBMCC is a private cancer research lab in Luxembourg with a team of 10 researchers dedicated to basic and translational cancer research about :

  • Cell death modalities;
  • Hematopoiesis, anemia, inflammation;
  • Epigenetics;
  • Identification / validation of biomarkers for prognosis and therapeutic response.
  • The lab’s working language is English.

    Further information about LBMCC and recent publications :

    https : / / www.researchgate.net / profile / Marc Diederich

    https : / / scholar.google.com / citations?hl en&user 6lMbxyEAAAAJ

    https : / / lbmcc.mysciencework.com

    The candidate works in close collaboration with his supervisors and a bio-informatician and has :

  • a Master degree mainly focused on molecular / cell biology and biochemistry
  • bioinformatics background and skills in biostatistics (regression model, hypothesis testing, etc.)
  • experience in molecular and cell biology techniques with a focus on flow cytometry. Fluorescent microscopy and immunohistochemistry would be an advantage
  • Knowledge in Hematopoiesis / Leukemia and sphingolipid metabolism will be particularly appreciated
  • Familiar with statistical analysis support (GraphPad Prism)
  • a good biological knowledge background related to LBMCC’s research
  • Motivation, good communication and writing skills, excellent time management, rigour, objectivity and ability to work with others
  • Publications related to the project

  • M. Orsini, S. Chateauvieux, J. Rhim, A. Gaigneaux, D. Cheillan, C. Christov, M. Dicato,
  • F. Morceau, M. Diederich, Sphingolipid-mediated inflammatory signaling leading

    to autophagy inhibition converts erythropoiesis to myelopoiesis in human

    hematopoietic stem / progenitor cells. Cell Death Differ, (2019), 26, 1796-1812.

  • A. Trecul, F. Morceau, A. Gaigneaux, M. Schnekenburger, M. Dicato, M. Diederich,
  • Valproic acid regulates erythro-megakaryocytic differentiation through the

    modulation of transcription factors and microRNA regulatory micro-networks.

    Biochem Pharmacol, (2014), 92, 299-311.

  • A. Trecul, F. Morceau, A. Gaigneaux, M. Orsini, S. Chateauvieux, C. Grandjenette, M.
  • Dicato, M. Diederich, Polyphenol tri-vanillic ester 13c inhibits P-JAK2V617F and

    Bcr-Abl oncokinase expression in correlation with STAT3 / STAT5 inactivation

    and apoptosis induction in human leukemia cells. Cancer Lett,(2013), 340, 30-42.

  • S. Chateauvieux, S. Eifes, F. Morceau, C. Grigorakaki, M. Schnekenburger, E. Henry,
  • M. Dicato, M. Diederich, Valproic acid perturbs hematopoietic homeostasis by

    inhibition of erythroid differentiation and activation of the myelo-monocytic

    pathway. Biochem Pharmacol, (2011), 81, 498-509

    Please send a letter of interest, a CV and contact information of three references to :

    Prof. Marc Diederich

    Fondation de Recherche Cancer et Sang

    Laboratoire de Biologie Moléculaire et Cellulaire du Cancer (LBMCC)

    6A rue Nicolas-Ernest Barblé,

    L-1210 Luxembourg

    Email : marc.diederich(at)lbmcc.lu

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