About the University*
The *University of Luxembourg* aspires to be one of Europe’s most highly regarded universities with a distinctly international and *interdisciplinary character.
It fosters the cross-fertilisation of *research* and *teaching*, is relevant to its country, is known worldwide for its research and teaching in targeted areas, and is establishing itself as an innovative model for contemporary European Higher Education.
It s core asset is its well-connected world-class academic staff which will attract the most motivated, talented and creative students and young researchers who will learn to enjoy taking up challenges and develop into visionary thinkers able to shape society.
Within the University, the *Luxembourg Centre for Systems Biomedicine (LCSB)* is a highly interdisciplinary *research centre (IC)*, integrating experimental biology and computational biology approaches in order to develop the foundation of a future predictive, preventive and personalized medicine.
The Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg is a highly dynamic, multilingual and international working environment at campus Belval.
The Translational Neuroscience Group, led by Prof Rejko Krueger, creates a translational bridge between fundamental and the clinic with a focuse on Parkinson’s disease research, with the aim to improve diagnosis and therapy to help patients in Luxembourg and beyond.
We are currently looking for an energetic, highly motivated post-doctoral researcher for a collaborative fundamental biology research project in Parkinson’s Disease (PD).
Tasks / Activities*
The post-doctoral researcher will contribute to relevant projects of the Translational Neuroscience Group, in particular to the *investigation of the role of different models of α-syn pathogenicity in PD*
The aim of this project is to characterize patient-based cellular models, using induced pluripotent stem cells to gain essential knowledge with respect to the molecular mechanisms involved in the pathogenesis of PD.
These models then will be explored for serving as cellular readouts for genetic and pharmacological modifications to revert disease associated phenotypes and to disentangle functional networks related to neurodegeneration.
Specific tasks can include : *
conduct research processes to achieve the goals of the project in an interdisciplinary team approach
develop methodologies and integrate new technologies
collect, assemble and evaluate research data
analyses and interpretation of results obtained
writing scientific publications and grant applications
contribution to research reports
perform advanced molecular and cellular biological experiments such as cloning, gene-editing (CrisPR), qPCR
generation of viral expression constructs and transduction of patient based cellular models
perform various biochemical assays and protein purifications
culture of induced pluripotent stem cells (iPSC) into different CNS-related cell types including 3D cultures (organoids)
development and application of functional readouts for different mitochondrial and neuronal phenotypes
presenting the results at national and international scientific meetings as posters or talks
PhD in Cellular Biology, Neuroscience, or related discipline
strong interest in interdisciplinary research and cellular models of neurodegeneration
experience in research and laboratory work
profound knowledge of molecular genetics, biochemistry and cell biology
expertise with inducible pluripotent stem cell models for 2D and 3D cultures
previous experience with CRISPR / Cas9 gene editing desirable
excellent team-working and interpersonal skills
enthusiasm and great commitment to research
excellent command of the English language
exciting international and interdisciplinary research environment
travel opportunities to national and international meetings as well as participation in specialized trainings
an excellent international network in the area of neurodegenerative research
the University of Luxembourg offers highly competitive salaries based on the candidate's experience and is an equal opportunity employer
Contract Type : 12 months fixed-term contract
Work Hours : Full Time Hours per Week
Starting date : as soon as possible
Location : Belval
Job Reference : UOL03642