Post-Doctoral Researcher in Proteomics - GD1217
All human cells need oxygen for energy production by oxidative phosphorylation. If the oxygen levels are low, cells switch from oxidative phosphorylation to glycolysis.
This switch is important for the development and progression of cancer cells as the distribution of nutrients in the tumor is limited, and the center of the tumor is starving.
By switching from oxidative phosphorylation to glycolysis, the tumor can escape many treatment options and lead to a detrimental outcome for the cancer patient
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The switch is regulated by the oxygen level dependent formation of hydroxyproline on the Hif1α subunit which in turn is recognized by the VHL-E3 ligase leading to Hif1α’s degradation by the ubiquitin-proteasome system.
In addition to these modifications, a number of large-scale studies aimed at post-translationally modified (PTM) proteins identified 60 other PTMs on Hif1α.
The regulatory function of these modifications is largely unknown. In this project, we are setting out to define a comprehensive interactome of Hif1α and its regulation by PTMs.
The goal is to identify other regulatory pathways which are involved in Hif1α regulation and signaling.
The proteomics laboratory is equipped with the latest instrumentation in high-resolution mass spectrometry. Close collaborations with the other groups of the LIH offer a broad spectrum of modern techniques.
Especially the close collaborations of the proteomics laboratory with the bioinformatics group allows the rapid development of specialized methods and tools to address specific scientific challenges.
KEY SKILLS, EXPERIENCE AND QUALIFICATIONS
Researchers are supported by easy access to scientific expertise, well-equipped facilities, an active seminar program as well as the possibility for close collaborations with the university and other research institutes.
REF. : VD / PDRP1217 / GD / GENPRO
3 year fixed-term contract, full time, start date : 1st February 2018