Luxembourg Institute of Health (LIH) is the leading public research center in Luxembourg for basic, pre-clinical and clinical research in biomedicine and public health.
Our clinically-oriented biomedical research activities in Oncology, Infection & Immunity and Population Health encompass the generation of knowledge on the pathogenesis, diagnosis and treatment of diseases with large impacts on public health and the epidemiological surveillance of these diseases.
With the mission to deliver scientific, economic and societal value for Luxembourg, LIH aims to translate knowledge into clinical applications impacting on healthcare systems while shaping personalized medicine
Background. Chronic Lymphocytic Leukemia (CLL) represent the most frequent leukemia in adults. Despite recent advances in treatments, CLL remains a deadly uncurable disease.
This cancer is characterized by an accumulation of abnormal, apoptosis resistant, B lymphocytes in the blood and lymphoid organs of the patients.
CLL progression is highly dependent on complex interactions between tumor cells and their microenvironment. Indeed, CLL cells can modify stromal cells and immune cells to promote their survival and to escape from the immune surveillance system.
Objectives. Our team focuses on the mechanisms leading to leukemia progression, in particular the influence of CLL cells on stromal cells and immune cells located in their microenvironment, with the goal to identify new prognostic markers and therapeutic targets.
Training and research environment . Tumor Stroma Interactions research group is a dynamic and multinational team whose current members originate from France, Belgium, Germany, Italy, Spain and Argentina.
It belongs to the , whose research activities focus on the cellular and molecular mechanisms of tumor progression using a wide range of cutting edge technologies, including mass cytometry, transcriptomic and proteomic analyses, as well as in vitro and in vivo techniques using state-of-the art animal models for cancer research.
Master students will assist one of our projects that aims to explore the interplay between leukemic cells and their microenvironment, and will be co-supervised by Dr.
E. Moussay (PI), Dr. J. Paggetti (PI) and experienced scientists from the team.
Selected references (open access) : Paggetti J, et al. Exosomes released by chronic lymphocytic leukemia cells induce cancer-associated fibroblast formation.Blood 126(9) : 1106-17.
Wierz M, et al. Dual PD1 / LAG3 immune checkpoint blockade limits tumor development in a murine model of chronic lymphocytic leukemia.
Blood 131(14) : 1617-1621. (IF : 15.132)
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