Laboratory Technician on project in Translational Neuroscience
Université du Luxembourg
Belval, Esch-sur-Alzette, LU
il y a 6j

The University About us...

The University of Luxembourg is an international research university with a distinctly multilingual and interdisciplinary character.

The University was founded in 2003 and counts more than 6,700 students and more than 2,000 employees from around the world.

The University’s faculties and interdisciplinary centres ;focus on research in the areas of Computer Science and ICT Security, Materials Science, European and International Law, Finance and Financial Innovation, Education, Contemporary and Digital History.

In addition, the University focuses on cross-disciplinary research in the areas of Data Modelling and Simulation as well as Health and System Biomedicine.

Times Higher Education ranks the University of Luxembourg #3 worldwide for its international outlook, #20 in the Young University Ranking 2021 and among the top 250 universities worldwide.

Within the University, the Luxembourg Centre for Systems Biomedicine (LCSB) is a highly interdisciplinary research centre (IC), integrating experimental biology and computational biology approaches in order to develop the foundation of a future predictive, preventive and personalized medicine.

The Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg is a highly dynamic, multilingual and international working environment at campus Belval.

The Translational Neuroscience Group, led by Prof Rejko Krüger, creates a translational bridge between fundamental and the clinic with a focus on Parkinson’s disease research, with the aim to improve diagnosis and therapy to help patients in Luxembourg and beyond.

We are currently looking for an energetic, highly motivated Laboratory Technician for working on collaborative fundamental biology research projects in Parkinson’s disease (PD).

In particular, this position is supported by an FNR research grant to Dr. Giuseppe Arena, aimed at characterizing the link between PD and Type 2 Diabetes (T2D), in order to identify shared dysregulated pathways (e.

g. mitochondrial dysfunction, metabolic alterations) between the two diseases.

Your Role...

The technician Laboratory technician will support the research team in Translational Neuroscience regarding the organization of the lab (ordering, supply), perform experiments, obtain training in maintenance of lab automation (automated pipetting, cell culture) and assist in research and development of cellular models of Parkinson’s disease and Type 2 Diabetes (human cell lines, fibroblasts, induced pluripotent stem cells, iPSC-derived neurons and pancreatic beta cells) at LCSB.

In particular, the technician will support projects to characterize patient-based cellular models, e.g. using induced pluripotent stem cells-derived neurons and human pancreatic beta cells to gain essential knowledge with respect to the molecular mechanisms involved in the pathogenesis of PD and T2D.

These models will be then explored for serving as cellular readouts for genetic and pharmacological intervention to revert disease associated phenotypes and to disentangle functional networks related to neurodegeneration.

Specific tasks can include :

  • Conduct cultures of human induced pluripotent stem cells (iPSC cells), iPSC-derived neurons, pancreatic beta cells
  • Perform differentiation of iPSC cells into various lineages, including dopaminergic neurons
  • Work with bacteria and lentiviruses
  • Extract DNA, RNA, proteins from iPSC-derived neurons and pancreatic beta cells. These will be used for subsequent analyses including transcriptomics and metabolomics
  • Perform molecular biology experiments such as RT-qPCR
  • BCA protein quantification assay & Western blot
  • Perform various biochemical assays
  • Conduct immunofluorescence stainings of various cell types
  • Perform flow cytometry
  • Maintain a clean laboratory setting
  • Place orders for lab supply and inventory for laboratory use
  • Make-up and maintain stock / working chemical solutions and growth media
  • What we expect from you

  • A technical degree or equivalent in molecular biology, microbiology, biochemistry, bioengineering, biology or similar
  • Excellent organizational skills
  • Good computer skills for standard software (Excel, Word, etc) and specific tools (LaTeX, ImageJ Fiji, Graphpad Prism)
  • Flexible regarding research stays in collaborators’ research laboratories
  • Good command of English and French or German; knowledge Luxembourgish is considered to be an advantage
  • We offer...

  • An enthusiastic interdisciplinary team of basic scientists and clinical researchers in the area of Parkinson’s disease / Neurodegeneration
  • Opportunity to participate in the development of new concepts for the understanding and modulation of Parkinson’s disease as a common disorder
  • An excellent international network in the area of neurodegenerative research
  • In Short...

  • Contract Type : Contrat à durée déterminée 21 Mois
  • Work Hours : Full Time 40.0 Heures par Semaine
  • Starting date : 15 September 2022
  • Location : Belval
  • Internal Title : Research support technician
  • Job Reference : UOL04965
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