Research & Development specialist in Systems Biomedicine with focus on disease modeling
University of Luxembourg
Luxembourg, Luxembourg  
il y a 17h
source : Academic Media Group International AB

The University of Luxembourg aspires to be one of Europe’s most highly regarded universities with a distinctly international and interdisciplinary character .

It fosters the cross-fertilisation of research and teaching , is relevant to its country, is known worldwide for its research and teaching in targeted areas, and is establishing itself as an innovative model for contemporary European Higher Education.

The University s core asset is its well-connected world-class academic staff which will attract the most motivated, talented and creative students and young researchers who will learn to enjoy taking up challenges and develop into visionary thinkers able to shape society.

Within the University, the Luxembourg Centre for Systems Biomedicine (LCSB) is a highly interdisciplinary research centre (IC), integrating experimental biology and computational biology approaches in order to develop the foundation of a future predictive, preventive and personalized medicine.

Area : the applicant will be a member of the Enzymology & Metabolism Research Group headed by Assist. Prof. Dr. Carole Linster at the LCSB.

The Group’s research currently focuses on elucidating the physiological functions of more recently identified metabolic enzymes and on developing strategies for accelerating enzyme function discovery.

A second central topic is the generation of disease models for selected inborn errors of metabolism to study underlying disease mechanisms and / or investigate treatment options.

The group develops advanced phenotyping techniques, including metabolomics, to address related research questions and uses the budding yeast, zebrafish, and mammalian cell culture, including iPSC-derived cells, as main model systems.

Your Role

We seek a highly skilled and motivated researcher to develop an EU-funded project within an international consortium that focuses on two rare disorders of lysine metabolism causing debilitating and progressive neurological symptoms in young children.

In brief, the Luxembourg contribution to the project includes the generation and deep characterization of several in vivo disease models using zebrafish to ultimately evaluate a number of innovative strategies to improve early diagnosis and early implementation of personalized therapies to enhance long-term health outcomes and patients’ quality of life.

More specifically your tasks will include :

  • Generation of stable mutant lines (via CRISPR / Cas9 gene editing) in zebrafish
  • Performance of experiments using zebrafish embryos / larvae, e.g. microinjections, behavioral tests, open field recordings, immunohistochemistry
  • Performance of molecular biology experiments, such as PCR-based genotyping, cloning
  • Performance of metabolomics experiments, such as extractions, LC-MS metabolite analysis
  • Modern data management and precise project documentation
  • Active meeting participation and reporting within the international consortium
  • Capacity to work in a collaborative environment among different service-based platforms, e.g. aquatic, metabolomics, microscopy
  • Ordering consumables and maintaining stocks
  • Maintenance of a clean laboratory setting
  • Active participation in group meetings
  • Your Profile

  • A Master’s degree in biochemistry, molecular biology, genetics, neurosciences, biotechnology or another similar life science related discipline
  • Previous work in the field of metabolic biochemistry and / or neurosciences will be considered as an advantage
  • Experience with molecular biology techniques is essential
  • Experience with working with animals is essential (animal laboratory science certificate Function A or B according to the European Directive 2010 / 63 / EU is required).
  • Previous experience with aquaculture techniques and / or with zebrafish will be considered as an advantage

  • Excellent organizational and management skills
  • Excellent communication skills
  • Strong computational skills
  • Fluency in oral and written English is essential
  • We offer

  • A key role in cutting-edge research projects related to modeling human diseases
  • Opportunity to work in an exciting international, interdisciplinary research environment
  • Opportunity to participate in the development of the group’s research
  • Opportunity for professional trainings
  • In Short

  • Contract Type : Fixed Term Contract 24 Month with possible extension
  • Work Hours : Full Time 40.0 Hours per Week
  • Location : Belval
  • Foreseen starting date : May 2021
  • Job Reference : UOL04035
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