18 PhD Student positions in Molecular, Organellar and Cellular Quality Control in Parkinson
Luxembourg Institute of Health
Strassen, Luxembourg
il y a 15j

reseach area

The PARK-QC Doctoral Training Unit will focus on an interdisciplinary approach to investigate the functional network of molecular, organellar and cellular quality control pathways in the development of neurodegenerative diseases by dissecting the underlying pathological mechanisms.

The strength of network-based approaches offers the possibility of integrating newly identified genetic perturbations of the surveillance machinery via cutting-

edge gene-editing technologies, thereby allowing improvement of our animal- and cell-based models introducing ageing-related effects.

Within this innovative approach, we integrate additional genetic risk variants to established monogenic disease and thereby increase the effect of genes on phenotypes more than the sum of their individual contributions as drug targets.

Induced pluripotent stem cell derived neuronal models will be applied to innovative automated cell culture and compound screening platforms and application of advanced machine-

learning algorithms will allow identification of associated biomarkers of disease in order to find novel approaches to improve diagnosis and treatments.

An integral part of this DTU will be the development of novel protective therapeutic strategies.

your role

The training programme focuses on the following research topics :

  • Development of advanced disease models addressing different aspects of molecular, organellar and cellular quality control in neurodegeneration;
  • Identification and integration of molecular mechanisms into networks applying state-of-the-art omics, single-cell and computational modelling technologies;
  • Integrating molecular and cellular signatures into network-based modelling approaches to identify biomarkers for neurodegeneration;
  • Development of experimental readouts to conceptualize novel neuroprotective treatments based on genetic and pharmacological screening.
  • your profile

  • A Master degree or equivalent in Molecular Biology, Neuroscience, Computational Biology, Computer Science, Engineering, Physics, or related discipline;
  • Strong interest in interdisciplinary research and cellular models of neurodegeneration;
  • Profound knowledge of neurology, molecular and cellular biology, immunology, molecular genetics or related discipline;
  • Expertise with iPSC technology desirable;
  • Excellent communication, team-working and interpersonal skills;
  • Enthusiasm and great commitment to research;
  • Very good command of the English language.
  • Application phase

    Applications (in English) must be sent ONLINE contain the following documents :

  • Detailed Curriculum Vitae;
  • Cover letter mentioning the reference number;
  • List of publications (if any);
  • Description of past research experience and future interests;
  • Name and addresses of three referees.
  • As well as a short essay answering all the following questions :

  • What is your understanding of interdisciplinary research?
  • Give a situation where you have been proactive to solve a research problem?
  • What could be your contribution to the PARK-QC doctoral training unit and its research outcome?
  • ref. : R-AGR-3389-10-C (DTU Park-QC PRIDE)

    Please apply online until 25th of May 2018 via the following link : https : / / tinyurl.com / yc2shcbh

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