The PARK-QC Doctoral Training Unit will focus on an interdisciplinary approach to investigate the functional network of molecular, organellar and cellular quality control pathways in the development of neurodegenerative diseases by dissecting the underlying pathological mechanisms.
The strength of network-based approaches offers the possibility of integrating newly identified genetic perturbations of the surveillance machinery via cutting-
edge gene-editing technologies, thereby allowing improvement of our animal- and cell-based models introducing ageing-related effects.
Within this innovative approach, we integrate additional genetic risk variants to established monogenic disease and thereby increase the effect of genes on phenotypes more than the sum of their individual contributions as drug targets.
Induced pluripotent stem cell derived neuronal models will be applied to innovative automated cell culture and compound screening platforms and application of advanced machine-
learning algorithms will allow identification of associated biomarkers of disease in order to find novel approaches to improve diagnosis and treatments.
An integral part of this DTU will be the development of novel protective therapeutic strategies.
The training programme focuses on the following research topics :
Applications (in English) must be sent ONLINE contain the following documents :
As well as a short essay answering all the following questions :
ref. : R-AGR-3389-10-C (DTU Park-QC PRIDE)
Please apply online until 25th of May 2018 via the following link : https : / / tinyurl.com / yc2shcbh