Doctoral Candidate (PhD student) in Disease Modelling, Metabolomics, and Chemical Biology (m/f)
Université du Luxembourg
Luxembourg, Luxembourg
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The University of Luxembourg is a multilingual, international research University. Luxembourg is a dynamic, multicultural country in the heart of Europe with a strong research and development base supported by important organisational resources.

The Luxembourg Centre for Systems Biomedicine (LCSB) at the University of Luxembourg, offers state-of-the-art facilities and an excellent training environment for early-

stage researchers, in particular in the biomedical sciences.

The Enzymology & Metabolism Research Group at the LCSB is looking to hire a PhD student as part of the PARK-QC DTU , an interdisciplinary doctoral training unit focusing on Molecular, Organellar and Cellular Quality Control in Parkinson's disease and Other Neurodegenerative Diseases’ and involving several Luxembourgish biomedical research units.

Within the EM group, the project entitled The Role of Metabolite Repair, a New Type of Molecular Quality Control, in the Protection Against Neurodegeneration ’ will investigate the mechanism through which mutations in two metabolite repair genes cause severe neurological impairments in children and explore therapeutic strategies.

The successful PhD candidate will establish and analyse cellular or whole organism models of the disease, applying Crispr / Cas9 technology and metabolomics as well as imaging-

based phenotypic approaches. These models and defined phenotypic readouts will be applied to test small molecule therapeutic treatments.

Doctoral Candidate (PhD student) in Disease Modelling, Metabolomics, and Chemical Biology (m / f)

  • Ref : 50013576 (R-AGR-3389-11-C) PARK-QC DTU
  • Initial 14 months fixed-term-contract, renewable depending on thesis progress evaluation.
  • Full-time position (40h / week)
  • Student and employee status (36 months studies programme, as per university standards) with project funding available for up to 48 months
  • Earliest starting date November 1st, 2018 (position will be advertised until filled)
  • Your Profile

  • Master degree in Biochemistry, Biology, Molecular Biology, Biotechnology, Genetics or a related discipline.
  • Strong background in metabolic biochemistry and molecular / cellular biology, as well as good notions in bioinformatics.
  • Previous experience with handling model organisms, mammalian cell culture, and / or mass spectrometry techniques will be considered as important asset(s).
  • Excellent English writing and speaking skills are essential.
  • We offer

    36 months studies programme, as per university standards) with project funding available for up to 48 months

  • Competitive remuneration; contract subject to public national security system benefits
  • A dynamic, exciting and equal opportunity international research environment
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