NoSTra-ED - Novel Strategies for assessingexposure to short-lived endocrine disruptors.
Biological fluids (blood andurine), which are considered the matrices of choice for the assessment of humanexposure to pollutants, are of limited use for short-
life endocrine disruptors(e.g. bisphenol A, phthalates ). The main limit is related to the strongshort-term variability of the concentration of these molecules in thesematrices.
On the contrary, hair analysis provides information that integratesexposure over longer period and therefore represents a particularly interestingalternative.
The objective of the NoStra-ED project is to determine thevariability of the urinary concentration of short-life endocrine disruptors andto compare the information obtained from two matrices (urine and hair) for thebiomonitoring of human exposure to these pollutants within a follow-
up on humanvolunteers and animal experimentation. As part of this Master II internship,the candidate will be trained in various state-
of-the-art analytical techniquessuch as liquid and gas chromatography coupled with tandem mass spectrometricdetection (LC-
MS / MS and GC-MS / MS) as well as pre-analytical work(extraction from biological matrices, purification and concentration ofextracts) with the support of highly skilled engineers.
The candidate may alsoparticipate in the analysis and processing of the data produced : resultsformatting and interpretation, and statistical analysis under the supervisionof a statistician specialized in the field of biomonitoring
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