We are seeking two highly motivated post-doctoral researchers to study the spatio-temporal control of TGF beta signalling in epithelial cells.
The project combines state-of-the-art cell biological (CRISPR / Cas9 genome editing), proteomics (multiplex quantitative proximity proteomics) and imaging (light and electron microscopy, correlative imaging, 3D tomography) techniques to address the role of endocytic trafficking in the regulation of this fundamental signalling pathway.
The project is a collaboration between the Dittmar laboratory at the Luxembourg Institute of Health (LIH) and the Sandin / Ludwig laboratory at the Nanyang Technological University (NTU) in Singapore, and so offers the unique opportunity to work in both Europe and Asia.
Both laboratories have strong expertise in their respective fields and joined to understand how TGF beta signaling is regulated in time and space.
Successful candidates will be employed at the LIH and have the opportunity to spend half of the project time in Singapore.
The proteomics laboratory at LIH is equipped with the latest instrumentation in high-resolution mass spectrometry. Close collaborations with other groups at LIH offer a broad spectrum of additional cutting-
edge techniques. The Sandin / Ludwig lab is part of the NTU Institute of Structural Biology (NISB), and is equipped with the latest high-
end electron microscopes for cryoEM and cellular EM imaging (Titan Krios, Arctica), various light microscopes, and EM sample preparation equipment.
Key Skills, experience and qualifications
PhD in the fields of either Structural Biology, Cell Biology or Biochemistry
Expertise in working with cell cultures and / or molecular biology tools
Experience in electron microscopy and / or light microscopy
Experience in proteomics techniques and / or protein biochemistry
Knowledge about signaling mechanisms in mammalian cells
Demonstrable capacity to communicate science, and perform multiple research tasks under time and resource constraints
Fluency in English is mandatory (English is the working language).
More information on the participating partner labs can be found here : www.lih.lu / dittmar,
http : / / sarasandinlab.com, http : / / nisb.ntu.edu.sg
Researchersaresupportedbyeasyaccesstoscientificexpertise,well-equippedfacilities,an activeseminarprogramaswellasthepossibilityforclosecollaborationswiththeuniversity andotherresearchinstitutes.
Applications including a cover letter, a CV, a list of publications and names of two referees should be submitted by 1st April 2018 through the apply button below.